Optimización del tratamiento de la sepsis en un paciente crítico. Criterios de sepsis/shock séptico. Recomendaciones de Sociedades Científicas. Evidencias de su aplicación
BIBLIOGRAFIA
1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801-10.
Consenso internacional de la definición actual de sepsis y shock séptico. En este consenso se abandona la utilización de los criterios SIRS y la diferenciación entre sepsis y sepsis grave.
2. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644-55.
3. Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med. 1997;25:1789-95.
4. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6.
5. Vincent JL, de Mendonça A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on «sepsis-related problems» of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26:1793-800.
6. Esteban A, Frutos-Vivar F, Ferguson ND, et al. Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med. 2007;35:1284-9.
7. Blanco J, Muriel-Bombín A, Sagredo V, et al. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care Lond Engl. 2008;12:R158.
8. Bouza C, López-Cuadrado T, Saz-Parkinson Z, et al Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011). BMC Infect Dis. 2014;14:3863.
9. Ferrer R, Artigas A, Levy MM, et al. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA. 2008;299:2294-303.
Estudio observacional multicentrico antes-después para valorar el impacto de una estrategia educativa basada en las recomendaciones de la Campaña Sobrevivir a la Sepsis en 59 UCIs españolas.
10. Levy MM, Rhodes A, Phillips GS, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med. 2014;40:1623-33.
11. Sánchez B, Ferrer R, Suarez D, et al. Declining mortality due to severe sepsis and septic shock in Spanish intensive care units: A two-cohort study in 2005 and 2011. Med Intensiva. 2017;41:28-37.
12. Suarez D, Ferrer R, Artigas A, et al. Cost-effectiveness of the Surviving Sepsis Campaign protocol for severe sepsis: a prospective nation-wide study in Spain. Intensive Care Med. 2011;37:444-52.
13. Esteban E, Belda S, García-Soler P, et al. A multifaceted educational intervention shortened time to antibiotic administration in children with severe sepsis and septic shock: ABISS Edusepsis pediatric study. Intensive Care Med. 2017;43:1916-8.
14. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43:304-77.
Guías internacionales del tratamiento de la sepsis (recomendaciones de la Campaña Sobrevivir a la Sepsis 2016)
15. Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42:1749-55.
Estudio retrospectivo multicéntrico basado en los datos recogidos en 165 UCIs de Europa, Sudamérica y EEUU durante la Campaña Sobrevivir a la Sepsis, que incluyó a 28.150 pacientes. Este estudio analiza la asociación entre el retraso en el inicio de la antibioterapia y el aumento de la mortalidad en los pacientes con sepsis.
16. Levy MM, Evans LE, Rhodes A. The Surviving Sepsis Campaign Bundle: 2018 update. Intensive Care Med. 2018;44:925-8.
Actualización del 2018 del paquete de medidas a instaurar en la primera hora de tratamiento de la sepsis según las Guías de la Campaña Sobrevivir a la Sepsis. Estas recomendaciones incluyen el inicio de la fluidoterapia en la primera hora de atención.
17. Morr M, Lukasz A, Rübig E, et al. Sepsis recognition in the emergency department – impact on quality of care and outcome? BMC Emerg Med. 2017;17:11.
18. García-Villalba E, Cano-Sánchez A, Alcaraz-García A, et al. Nomogram to predict a poor outcome in emergency patients with sepsis and at low risk of organ damage according to Sepsis-related Organ Failure Assessment (SOFA). Emerg Rev Soc Espanola Med Emerg. 2017;29:81-6.
19. Candel FJ, Borges Sá M, Belda S, et al. Current aspects in sepsis approach. Turning things around. Rev Espanola Quimioter Publicacion Of Soc Espanola Quimioter. 2018;31:298-315.
20. Zhang Z, Smischney NJ, Zhang H, et al. AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis. 2016;8:2654-65.
Revisión acerca de los métodos de diagnóstico e identificación precoz de los pacientes hospitalizados con sepsis
21. Raith EP, Udy AA, Bailey M, et al. Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. JAMA. 2017;317:290-300.
Validación externa de la capacidad predictiva de las escalas SOFA, qSOFA y de los criterios SIRS en una cohorte retrospectiva de 180.000 pacientes de Nueva Zelanda ingresados en una UCI con sospecha de infección. En este estudio la capacidad predictiva de la escala SOFA fue superior a qSOFA y a los criterios SIRS en los pacientes de UCI.
22. Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:762-74.
Diseño de la escala qSOFA a partir de una base de datos retrospectiva de más de 700.000 pacientes ingresados en 12 hospitales de Pensilvania. Los resultados de este análisis indican una mayor capacidad predictiva de la escala qSOFA frente a la escala SOFA en los pacientes ingresados fuera de la UCI.
23. Angus DC. Fusing Randomized Trials With Big Data: The Key to Self-learning Health Care Systems? JAMA. 2015;314:767-8.
24. de Dios B, Borges M, Smith TD, et al. Computerised sepsis protocol management. Description of an early warning system. Enferm Infecc Microbiol Clin. 2018;36:84-90.
25. Cross G, Bilgrami I, Eastwood G, et al. The epidemiology of sepsis during rapid response team reviews in a teaching hospital. Anaesth Intensive Care. 2015;43:193-8.
26. Milano PK, Desai SA, Eiting EA, et al. Sepsis Bundle Adherence Is Associated with Improved Survival in Severe Sepsis or Septic Shock. West J Emerg Med. 2018;19:774-81.
27. Nguyen HB, Corbett SW, Steele R, et al. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med. 2007;35:1105-12.
28. Warttig S, Alderson P, Evans DJ, et al. Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients. Cochrane Database Syst Rev. 2018;6:CD012404.
29. Ferreras Amez JM, Arribas Entrala B, Sarrat Torres MA, et al. Before-after study of the effect of implementing a sepsis code for emergency departments in the community of Aragon. Emerg Rev Soc Espanola Med Emerg. 2017;29:154-60.
30. Robert Boter N, Mòdol Deltell JM, Casas Garcia I, et al. Activation of a code sepsis in the emergency department is associated with a decrease in mortality. Med Clin (Barc). 2018;
31. Rodríguez-Baño J, Paño-Pardo JR, Alvarez-Rocha L, et al. Programas de optimización de uso de antimicrobianos (PROA) en hospitales españoles: documento de consenso GEIH-SEIMC, SEFH y SEMPSPH. Enfermedades Infecc Microbiol Clínica. 2012;30:22.e1-22.e23.
32. IDSA Sepsis Task Force. Infectious Diseases Society of America (IDSA) POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines. Clin Infect Dis Off Publ Infect Dis Soc Am. 2018;66:1631-5.
Posicionamiento de la IDSA en contra de administrar antibioterapia en la primera hora a todo paciente con sospecha de sepsis.
33. Klompas M, Calandra T, Singer M. Antibiotics for Sepsis-Finding the Equilibrium. JAMA. 2018;320:1433-4.
34. Liu VX, Fielding-Singh V, Greene JD, et al. The Timing of Early Antibiotics and Hospital Mortality in Sepsis. Am J Respir Crit Care Med. 2017;196:856-63.
35. Seymour CW, Gesten F, Prescott HC, et al. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med. 2017;376:2235-44.
36. Alam N, Oskam E, Stassen PM, et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018;6:40-50.
